Laboratory - Scale Enzymatic / Chemical Syntheses of D - and L - B - Chlorolactic Acid and D - and l - Potassium Glycidater
نویسنده
چکیده
Abstracfi This paper describes preparations of o(and r--) chlorolactic acids having enantiomeric excesses greater than 977o by o(and l-) lactate dehydrogenase catalyzed reduction of chloropyruvic acid with NADH. In syntheses carried out on 0.1{).5-mol scales, the NADH was regenerated in situ by using glucose 6-phosphate and glucose 6-phosphate dehydrogenase. The enantiomerically enriched chlorolactic acids were converted to the correspondingly enriched potassium salts of glycidic acid (epoxyacrylic acid) by treatment with potassium hydroxide.
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